Design and synthesis of active heparan sulfate-based probes.
نویسندگان
چکیده
A chemoenzymatic approach for synthesizing heparan sulfate oligosaccharides with a reactive diazoacetyl saccharide residue is reported. The resultant oligosaccharides were demonstrated to serve as specific inhibitors for heparan sulfate sulfotransferases, offering a new set of tools to probe the structural selectivity for heparan sulfate-binding proteins.
منابع مشابه
Chemoenzymatic design of heparan sulfate oligosaccharides.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 55 شماره
صفحات -
تاریخ انتشار 2015